(function(doc, html, url) { var widget = doc.createElement("div"); widget.innerHTML = html; var script = doc.currentScript; // e = a.currentScript; if (!script) { var scripts = doc.scripts; for (var i = 0; i < scripts.length; ++i) { script = scripts[i]; if (script.src && script.src.indexOf(url) != -1) break; } } script.parentElement.replaceChild(widget, script); }(document, '

Elucidation of the pathogenesis of S-nitrosylated modification in SBMA

What is it about?

Spinal and bulbar muscular atrophy (SBMA) is an X-linked and late-onset progressive neuromuscular disease caused by a CAG repeat (polyglutamine; polyQ) expansion in the androgen receptor (AR) gene caused by molecular mechanisms, which to the day remain elusive.

Why is it important?

S-nitrosylation (SNO) is a redox-triggered post-translational modification. SNO can serve as a significant regulator of signal transduction pathways, much like phosphorylation. Also, aging and late-onset can result in abnormal SNO reactions as well as several neurodegenerative diseases. However, it is unknown how SNO contributes to SBMA pathogenesis and whether SNO represents a target for therapy in SBMA.

Read more on Kudos…
The following have contributed to this page:
John Hildyard, antonella spinazzola, Valeria Di Leo, Konstantina Tetorou, Saif Haddad, Yasumasa Hashimoto, katie Addison, Elisa Villalobos, Lucie Taylor, Jessica Stoodley, and Arta Aghaeupour
' ,"url"));