190 E280A mutation carriers for early-onset Alzheimer's disease were followed for more than 20 years, from 1995 to 2015, observing the age at which they presented any symptoms of depression and when they started with memory loss. The main objective of the study was to determine if the presence of depressive symptoms, years of education, marital status, rural or urban place of residence, or medical history accelerated or delayed the onset of the disease. People with a history of depression deteriorate almost twice as fast compared to those who do not present depression. And in total, having depressive symptoms accelerated the age of onset of dementia between 3 to 5 years, depending on other genes involved. This fact means that these people worsened faster, promptly needing help in all activities of daily living, such as talking, walking, or eating. Marital status also seems to be involved in this rapid progression of the disease. People without a stable partner (single, widowed, separated); presented cognitive impairment 3 years earlier compared to those who were married or in a free union. Within the medical history, it was found that individuals who suffered from thyroid but had treatment presented dementia later. Age was delayed between 5 to 9 years, and death was between 4 to 9 years.