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Oligomeric Aβ Correlates with performance on the Visual Cognitive Assessment Test

What is it about?

Oligomeric amyloid β (OAβ), an upstream driver of Alzheimer’s disease (AD) neuropathology, correlates well with cognitive performance as measured by the language neutral Visual Cognitive Assessment Test (VCAT), as well as grey matter volume (GMV) in a Southeast Asian cohort of mild cognitive impairment (MCI) patients. Higher plasma OAβ levels significantly correlated with lower cognitive scores (VCAT, Mini-Mental State Examination) and greater brain atrophy as measured by GMV.

Why is it important?

Such findings are noteworthy as they reveal the clinical utility of plasma OAβ as a promising blood-based biomarker that can be routinely used in the clinic to support clinicians in making a diagnosis of AD.

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Nagaendran Kandiah
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