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Abeta lowering does not increase bleeding in the brain of mice.

What is it about?

Study tests chronic effects of beta-secretase inhibition on the magnitude of microbleeds in the brains of mice engineered to develop amyloid plaques characteristic of Alzheimer's disease. Microbleeds or microhemmorhages are commonly observe in AD patients and experimental therapies that alter the status of amyloid plaques can elevate microbleeds.

Why is it important?

Study informed on the safety risks for beta-secretase inhibition to cause microbleeds in AD patients treated with the beta-secretase inhibitor verubecestat

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Matthew Kennedy
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