The ERP MAPT PLUS study
What is it about?
A better knowledge of Alzheimer’s disease (AD) physiopathology highlighted synaptic dysfunction as a primarily pathological process mediated by the toxicity of soluble Aβ oligomers. It’s well known that event-related potential (ERP) method, because particularly accessible to non-invasive study provides a sensitive measure of synaptic dysfunction at early stages of AD. Nowadays, we stress the need for developing a simple noninvasive screening tool for a reliable identification of elderly subjects who display underlying AD lesions at preclinical stage. Findings from our clinical study show that ERP display a good predictive value for the presence of brain amyloid load in elderly subjects at risk to develop AD.
Why is it important?
Our project will bring the possibility of developing a simple screening tool for a “timely diagnosis” that could improve the screening of the patients in clinical trials without invasive explorations.