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mechanisms of neurodegenerative diseases, blood-brain barrier

What is it about?

Genetic factors play important roles in Alzheimer's pathogenesis. One of the top genetic risk factors is ABCA7. This work indicates that the genetic variations (single nucleotide polymorphisms) identified in large cohorts of genetic studies dysregulated ABCA7 expression or enhanced BACE1 activity and beta-amyloid production in cells.

Why is it important?

This work helps to understand the functional roles of those genetic variaions in the pathogenesis of Alzheimer's disease.

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The following have contributed to this page:
Wandong Zhang
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