Expression level of non-coding (MiR-155) gene as biomarker for severity of coronaviruses infection
What is it about?
The COVID-19 pandemic caused by SARS-CoV-2 is influenced by genetic and epigenetic factors, including miR-155, which affects immune cell and virus functions and laboratory biomarkers. This study evaluates miR-155's role as a biomarker for SARS-CoV-2 detection and monitoring, examining its significance in identifying infection in both vaccinated and unvaccinated individuals using ROC curve analysis. Among the miRNAs, miRNA-155 (miR-155) has been thoroughly examined in individuals with SARS-CoV-2 that is either severe or mild. According to reports, people infected with SARS-CoV-2 may be instructed to trigger a cytokine storm or strong pro-inflammatory reactions. CRP and miR-155 exhibited a strong and positive correlation, Consequently, the molecules have the capacity to control the expression of the viral and immune system proteins inside the host cells. Based on these findings, MiR-155 has been shown to have a major role in the pathophysiology and severity of SARS-CoV-2, and it may be used as a clinical biomarker for early infection severity and detections
Why is it important?
Our results are shown. Research on miR-155 and its connection to the SARS-CoV-2 virus is essential for gaining insights into the underlying mechanisms of SARS-CoV-2 pathogenesis. Investigating the role of miR-155 as a potential biomarker could provide valuable information for developing effective diagnostic and therapeutic strategies for SARS-CoV-2.