What is it about?
Studies of the dynamics (3,7,14,21 days) of healing the burn wound on the skin of white adult male rats of the line were conducted. The content of nuclear factor kappa B (NF-κB), vascular endothelial growth factor (VEGF), its receptor (Flt-1) in the regenerate tissue was studied by Western blot analysis, regenerate cells and peripheral blood (PB) were counted and bone marrow myelogram (BM) was conducted.
Why is it important?
It was found, that Blood neutrophils are the main donors of VEGF and stimulate the expression of the FLT-1 receptor. On the background of hyperglycemia in the regenerate there is a state of chronic inflammation, imbalance of receptor and ligand of angiogenesis: VEGF and FLT-1, which deepen hypoxia, prevent the physiological course of burn wound healing, and maybe an important factor in impaired tissue regeneration in diabetes.