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Alzheimer's rats with a preference for one side

What is it about?

TgF344-AD rats carry two mutant genes associated with the early onset of Alzheimer's disease in humans, typically occurring before the age of 65. Our study reveals that these genes not only cause memory loss in rats but also unilateral spatial neglect, a condition shared with Alzheimer's patients that hinders their ability to pay attention to objects on one side of their body. Much like Alzheimer's patients, spatial neglect in rats was accompanied by neurodegeneration, primarily affecting one side of the brain. Having a rat model that not only possesses the same genes but also exhibits the same symptoms as Alzheimer's patients allows researchers to develop new therapies for this so far incurable disease.

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The following have contributed to this page:
Boriss Sagalajev
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