Monocyte/macrophages inflammation is inhibited by a Gi-protein inhibitor encapsulated in liposomes
What is it about?
Monocytes and macrophages play critical roles in inflammatory and immune responses; therefore, the modulation of their functions is a useful strategy for anti-inflammatory therapies, including nanotherapies. Lipopolysaccharide (LPS) can cause an acute inflammatory response by triggering the release of a vast number of inflammatory cytokines in various cell types, including monocytes/macrophages. Gi proteins mediate LPS effects in monocytes/macrophages. GOT is a potent Gi inhibitor, and reduces inflammation in vascular cells In this study we show that GOT encapsulated in liposomes (Lipo/GOT) blocked inflammatory mediators production by LPS in monocytes/macrophages while free Got showed reduced or no effects..
Why is it important?
Our findings demonstrate the potential of liposome-encapsulated GOT, as a novel nanotherapy to block LPS proinflammatory effects in monocytes/macrophages.