Mental disorders are the greatest contributor to disease burden worldwide, but there is an enormous lack of mental health specialists to provide care for these disorders, particularly in developing countries. This study will determine how to increase access to mental health services by training non-specialists to provide mental health care in community and health care settings in Mozambique, one of the poorest nations in the world. Study findings will inform the creation of a toolkit to guide implementation of services to treat mental disorders in Mozambique in a cost-effective manner. This work is conducted in collaboration with the Mozambican Ministry of Health, so the toolkit will be applied to national policy and practice related to mental health care, and may be used as a model in other low-resource settings.