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Anterior Cingulate Mitochondrial Dysfunction in Autism: A Positron Emission Tomography Study

What is it about?

Previous studies of postmortem brains or peripheral samples have suggested a role of mitochondrial dysfunction in the pathophysiology of autism spectrum disorder. The current case-control positron emission tomography study demonstrated the significantly low mitochondrial electron transport chain complex I availability in anterior cingulate cortex of psychotropics-free participants with high-functioning autism spectrum disorder compared with age-, sex-, parental socioeconomical status-, and intelligence level-matched typically developed controls, and further revealed their significant correlations with severe sociocommunicational autism core symptom.

Why is it important?

The present study provided the first and direct in vivo human brain evidence linking mitochondrial dysfunction to the core feature of autism spectrum disorder.

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Hidenori Yamasue
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