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Non-Replication of Brain-Based Biotypes of PTSD

What is it about?

This conceptual replication study aimed to test whether distinct functional MRI patterns of threat and reward reactivity are associated with post-traumatic symptoms. Identified clusters were not identical to the previously identified brain-based biotypes and were not associated with prospective symptoms of posttraumatic psychopathology.

Why is it important?

Because we show that even small changes in sample characteristics or experimental tasks can greatly impact the replicability of neuroimaging-based biotypes and their link to prospective clinical symptoms. Caution is warranted before treatment implications can be fully realized. Replication attempts are the key to moving forward and discovering stable & generalizable brain-based biotypes of psychiatric disorders!

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The following have contributed to this page:
Ziv Ben-Zion
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