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X-Ray crystal structure of a benzamide bearing 4-aminoantipyrine

What is it about?

The paper describes high-throughput (HTP) encapsulated nanodroplet crystallization (ENaCt) method and the X-ray structure of of a benzamide bearing 4-aminoantipyrine. The benzamide was synthesized following standard amide synthesis protocols. The goal was Ru-catalyzed C-H bond arylation with aryl bromides that we reported to be successful.

Why is it important?

The high-throughput (HTP) encapsulated nanodroplet crystallization (ENaCt) performed on the 2-methylbenzamide bearing 4-aminoantipyrine paved the way for X-ray structure determination. The X-ray structure provided conclusive evidence for the benzamide structure. Therefore, laying ground for conclusive confirmation of regioselectivity/site-selectivity of the successful Ru-catalyzed ortho-C-H bond arylation.

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The following have contributed to this page:
Hamad Al Mamari
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