Synthesis, structure and cytotoxicity of Pt(II) complexes bearing natural arylolefin and quinoline
What is it about?
We have synthesized five new Pt(II) complexes of type trans-[PtCl2(AlkEug)(Qui)], (2) and (3), and [PtCl(amine)(AlkEug)], (4)-(6) with high yields (≥ 89%) and determined their structures by means of IR, ESI-MS and XRD methods. The results of testing in vitro cytotoxicity against KB, LU, Hep-G2 and MCF-7 cancer cell lines of (2)-(6) indicate that the excellent cytotoxicity (the IC50 values of 0.38-29.23 μM) indeed depends on the amine ligand and increases in the order: quinoline-2-carboxylate complex (6) < quinoline complexes (2) and (3) < quinoline-8-olate complexes (4) and (5). The IC50 values of the most promising complex (5) are at least 30 times lower than that of cisplatin.
Why is it important?
Our findings indicate the significant in vitro cytotoxicity of five new Pt(II) complexes against four human cancer cell lines and the unambiguous influence of the amine ligand on the cytotoxicity. This warrants further research the potential applications of the complexes in pharmaceutical.