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Peptide Bonds Unveiled: Enhancing Protein Structure Understanding

What is it about?

High-resolution crystal structures reveal that peptide bonds in α-helices exhibit more enol-like characteristics than those in β-strands, including potential protonation of peptide oxygen atoms.

Why is it important?

This study underscores the unique insights provided by high-resolution protein crystallography, uncovering peptide bond properties that have been overlooked by traditional methods such as crystallography, NMR, and cryo-EM. It calls for a reconsideration of local restraints in structure refinements, shedding light on peptide bond dynamics crucial for protein function.

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Santosh Panjikar
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