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Structural and immunological analysis of an endogenous plant glycoallergen

What is it about?

We describe the crystal structure of a natural allergen Hev b 2, (Beta-1,3-glucanase) that exhibits two glycosylation sites on its surface. These glycan moieties are asparagine-linked branched oligosaccharides with an alpha-1,3-fucosylation that has been associated with the allergenicity of plant and insect glycoproteins. Basophil cells stimulated with glycosylated Hev b 2 revealed greater cell activation and degranulation than the enzymatically deglycosylated allergen

Why is it important?

These carbohydrate moieties on the surface of Hev b 2 constitute an important epitope that might be responsible for the IgE cross-reactivity that is observed in the latex-fruit syndrome.

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Rodriguez-Romero Adela
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