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How in vitro experimental design may influence observed function in membrane fusion
What is it about?
This is a review of papers on membrane fusion, that looks to see if there is a link between experimental design and reported function (inhibitory, activating or both) for an important mammalian regulatory protein Munc18.
Why is it important?
The review suggests that removing the C-terminal membrane anchor from Syntaxin - the membrane protein partner of Munc18 - may influence the outcome of the experiment.