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An online webserver and database for the identification of contaminant crystals
What is it about?
Surprisingly frequently, the protein that crystallises is not the researcher's protein of interest, but a contaminant. In these cases, solving the phase problem becomes extremely time consuming. Our Webserver uses massively parallel molecular replacement with >60 known protein contaminants to solve this problem in 10 min to 4h.
Why is it important?
Use of our ContaMiner webserver can help X-ray crystallographers saving a lot of time and efforts. Moreover, ContaMiner can be used as a routine safety check for ‘crystallisation and preliminary X-ray analysis’ publications. The ContaBase is the result of a community effort, and contains currently the most exhaustive repository of protein contaminants.