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Interactions of DNA with the antiparasitic drug CD27
What is it about?
The Malaria, Chagas and Sleeping sicknesses, are spread around the world by diferent parasites. They have in common a DNA very rich in AT base pairs. We show how a derivative of diphenilamine interacts with all AT DNA.
Why is it important?
> The CD27 drug completely covers the whole minor groove of DNA and displaces bound water. The complex looks like a triple helix, with the third strand built by a continuous string of drug molecules. Thus it prevents the access to DNA of proteins such as AT-hook proteins and proteins related with transcription or replication of DNA. Also the drug interacts with neighbouring molecules and may act as a cross-linking agent.